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Markets fell Wednesday as robust US employment data and rising Treasury yields stoked fears that interest rates will be higher for longer.
The labour report, known as JOLTS, showed a surprise increase in the number of job openings to 9.6 million, a sign of continued tightness in the market and fuelling worries of a further rate hike by the Federal Reserve before year's end.
The figures come ahead of Friday's highly anticipated September US employment report, a key data point weighing on future interest rate decisions.
Following the JOLTS report, 10-year US Treasury note yields climbed to levels last seen in 2007. Treasury bond yields are seen as a proxy for US interest rates and are closely watched.
All three major US indices closed in the red, falling by more than one percent as the bond sell-off hit global equity markets.
"Stock market investors were sent reeling after US job openings unexpectedly rebounded in August, adding to concerns that the Federal Reserve could hike rates in November but unquestionably maintain elevated borrowing costs for an extended duration," said SPI Asset Management's Stephen Innes.
Tokyo and Seoul, which resumed trade after a long holiday weekend, led the Asian sell-off Wednesday, both falling more than two percent, while Hong Kong, Taipei, Jakarta, Singapore, Mumbai, Sydney and Wellington were all sharply lower in a sea of red. Bangkok was the sole gainer.
Markets in mainland China were closed for a week-long holiday.
The rout continued in Europe, with London, Frankfurt and Paris all down at the open.
"It is difficult (for investors) to move towards bargain-hunting as yields in US Treasury notes keep climbing," analyst Shutaro Yasuda of Tokai Tokyo Research Institute said.
On forex markets the yen was trading around 149 to the dollar after hitting 150.16 in London on Tuesday, its weakest level in a year.
Japan's top finance officials declined to comment Wednesday on whether Tokyo had intervened to support the yen after it had breached the psychological 150 level.
In recent months, the yen has plummeted against the dollar in part because of the widening gap in interest rates set by the Bank of Japan and the US Federal Reserve.
Oil was lower, with West Texas Intermediate trading below $90 a barrel and Brent at $90.32.
- Key figures around 0725 GMT -
Tokyo - Nikkei 225: DOWN 2.3 percent at 30,526.88 (close)
Hong Kong - Hang Seng Index: DOWN 1.1 percent at 17,145.19
Shanghai - Composite: Closed for a holiday
London - FTSE 100: DOWN 0.3 percent at 7,446.75
Euro/dollar: DOWN at $1.0466 from $1.0477 Tuesday
Pound/dollar: DOWN at $1.2066 from $1.2087
Euro/pound: UP at 86.74 pence from 86.68 pence
Dollar/yen: DOWN at 149.01 yen from 149.86 yen
Brent North Sea crude: DOWN 0.7 percent at $90.32 per barrel
West Texas Intermediate: DOWN 0.8 percent at $88.55 per barrel
New York - Dow: DOWN 1.3 percent at 33,002.38 (close)
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